There are several LPWAN radio technologies providing wireless communication to the billions of connected devices that form the so-called IoT. Among them, LoRa has emerged in recent years as a popular solution for low power embedded devices to transmit data at long distances on a reduced energy budget. Most often, LoRa is used as the physical layer of LoRaWAN, an open standard that defines a MAC layer and specifies the star-of-stars topology, operation, roles and mechanisms for an integrated, full-stack IoT architecture. Nowadays, millions of devices use LoRaWAN networks in all sorts of agriculture, smart cities and buildings, industry, logistics and utilities scenarios. Despite its success in all sorts of IoT domains and environments, there are still use cases that would benefit from more flexible network topologies than LoRaWAN’s star-of-stars. For instance, in scenarios where the deployment and operation of the backbone network infrastructure is technically or economically challenging, a more flexible model may improve certain performance metrics. As a first major contribution, this thesis investigates the effects of adding multi-hop capability to LoRaWAN, by means of the realistic use case of a communication system based on this architecture that provides a coordinated response in the aftermath of natural disasters like an earthquake. The capacity of end nodes to forward packets and perform multi-hop transmissions is explored, as a strategy to overcome gateway infrastructure failures, and analyzed for challenges, benefits and drawbacks in a massive system with thousands of devices. LoRa is also used as a stand-alone radio technology, independently from the LoRaWAN architecture. Its CSS modulation offers many advantages in LPWANs for IoT deployments. In particular, its different SFs available determine a trade-off between transmission time (i.e., data rate) and sensitivity (i.e., distance reach), and also generate quasi-orthogonal signals that can be demodulated concurrently by different receivers. The second major contribution of this thesis is the design of a minimalistic distance-vector routing protocol for embedded IoT devices featuring a LoRa transceiver, and the proposal of a path cost calculation metric that takes advantage of the multi-SF capability to reduce end-to-end transmission time. The protocol is evaluated through simulation and compared with other well-known routing strategies, analyzing and discussing its suitability for heterogeneous IoT LoRa mesh networks.